To reduce the risk of genital herpes, use a condom every time

We’ve assumed that condoms can reduce the spread of genital herpes – but without complete, or at least well-quantified, confidence in the assumption.

This fact sheet from the federal Centers for Disease Control and Prevention sums up the reason for such hesitation: “Genital ulcer diseases can occur in both male and female genital areas that are covered or protected by a latex condom, as well as in areas that are not covered.”

Then there’s the problem of transmission without visible signs of infection. As the National Institutes of Health states: “Most people get genital herpes by having sex with someone who is shedding the herpes virus either during an outbreak or an asymptomatic (without symptoms) period. People who do not know they have herpes play an important role in transmission because they are unaware they can infect a sexual partner.”

Researchers at the University of Washington, the federal Centers for Disease Control and Prevention and elsewhere decided to try to clarify just how much condoms can reduce the spread of genital herpes, known medically as herpes simplex virus 2 (or HSV-2).

They analyzed six studies of various types, all of which featured data on individual condom use and on HSV-2 acquisition.

They found that people who always used condoms had a 30% decreased risk of acquiring genital herpes when compared with people who never used condoms.

In clarifying further, the researchers stated: “Risk of HSV-2 acquisition decreased by 7% for every additional 25% of the time that condoms were used during anal or vaginal sex. Risk of HSV-2 acquisition also rose steadily and significantly with increasing frequency of unprotected sex acts, and our findings were consistent throughout multiple analysis strategies.”

The results were published today in the Archives of Internal Medicine. Here’s the abstract.

The upshot of the study: “Although the magnitude of protection was not as large as has been observed with other STIs, we found that condoms offer moderate protection against HSV-2 acquisition in men and women.”

Here’s more information on genital herpes from the National Institutes of Health, including details on asymptomatic shedding:

“Sometimes, the virus can become active but not cause any visible sores or any symptoms. During these times, small amounts of the virus may be shed at or near places of the first infection, in fluids from the mouth, penis, or vagina, or from barely noticeable sores. This is called asymptomatic shedding. Even though you are not aware of the shedding, you can infect a sexual partner during this time. Asymptomatic shedding is an important factor in the spread of herpes.”

And here’s the aforementioned fact sheet on genital herpes from the CDC.

The key here is consistent use. Not sometime use, but consistent use.

For the complete article, please refer to http://latimesblogs.latimes.com/booster_shots/2009/07/condoms-genital-herpes-.html

Minister Urges Firms to Pool HIV Patents

By 2030, an estimated 50 million people with HIV/AIDS will need newer treatments to keep them alive, according an all-party parliamentary report due out this week. To prevent millions of AIDS deaths in poor countries, pharmaceutical firms holding patents on HIV/AIDS drugs should release these drugs’ patent rights, Mike Foster, Britain’s international development minister, is expected to say.

Under the proposal, drug companies could put their HIV/AIDS drugs into a “patent pool,” and generic-drug makers would be permitted to make cheaper copies and combination pills for patients in poor nations. Unitaid, an international drug-buying entity set by up several donor countries including the United Kingdom, is trying to create the pool. However, drug firms regard patents as the means of recouping the massive costs of drug research and development.

Three million HIV/AIDS patients in poor countries now receive subsidized treatment, but that is just one-third of those in need. Drug resistance is a growing threat in both the developing and developed nations, and the newer treatments are expensive. Cheap, generic copies of these newer drugs cannot easily be made by generic-drug makers in places such as India and China, which now have tighter intellectual property-rights rules.

“The pharmaceutical industry has an opportunity to act now to help prevent future human catastrophe,” said Foster. “It is time for them to state their clear commitments to make HIV medicines affordable to those who need them most.”

“We are sitting on a treatment time bomb,” said Member of Parliament David Barrow, who chairs the all-party parliamentary group on AIDS. “We cannot sleepwalk into a situation where we can only afford to treat a tiny proportion of those infected.”

For the complete article, please refer to http://www.aegis.com/todaysnews/du.asp

Other sexually transmitted diseases don’t get the attention HIV does, which causes Dr. John Toney some distress

An estimated 19 million new infections occur each year, most of them not HIV. Almost half are in people 15- to 24 years old.
Chlamydia diagnoses are skyrocketing. Syphilis, at an all-time low nine years ago, is increasing steadily with a big boost in men.
Although its numbers are fairly stable nationwide, gonorrhea still occurs more than it should.
The southeastern United States has the highest rates of those three, said Toney, a professor with the University of South Florida College of Medicine’s infectious diseases division.
Getting people tested for STDs and teaching them how to keep from getting infected involves issues similar to those reported by Polk County’s HIV/AIDS outreach workers, Toney said.
HIV/AIDS gets the attention, in large part, because of the number of people who die from it. The statistics for other STDS didn’t seem as compelling or deadly, despite the sterility, infertility and pain they can cause.
But here are some statistics that can put STDs in a whole new light:
People infected with other STDS, like gonorrhea or syphilis, are at least 2-to-5 times more likely than uninfected people to get HIV infection when exposed to HIV during sex. That’s according to the federal Centers for Disease Control and Prevention. It’s true for all races.
Higher rates of poverty among blacks than whites, accompanied by socioeconomic barriers to prevention and treatment, are associated with their higher rates of both STDs and HIV.
Syphilis and herpes, producing sores and ulcers, make it much easier for the HIV virus to get into the body.
“You need less virus to cause an infection,” Toney said.
With gonorrhea and chlamydia, inflammation pushes cells that could get infected closer to the surface, again making HIV infection easier.
Blacks had about 70 percent of reported gonorrhea cases, 48 percent of all chlamydia cases and 46 percent of syphilis cases nationwide in 2007, the CDC reported. They’re about 12 percent of the population.
Black teenagers who are 15-to-19 years old have the highest rates of chlamydia or gonorrhea of any group, CDC said in January.
Black women were 16 times more likely to have syphilis than white women, 15 times more likely to have gonorrhea and seven times more likely to have chlamydia in 2006, according to the Black AIDS Institute’s report on “The State of AIDS in Black America 2009.”
Many cases of STDS don’t get diagnosed. Some don’t cause symptoms or the symptoms are mild. Some common viral infections, like human papillomavirus and genital herpes, don’t get reported.
Collectively, the CDC estimates STDs cost the U.S. health system as much as $15.3 billion a year.
Because of the link between HIV and other STDs, Polk County’s outreach workers often test for both when they’re doing community programs such as the one being held in Haines City today for National HIV Testing Day.
Combatting STDs has to take place through the offices of individual practitioners – doctors, nurses and advanced nurse practitioners – nationwide.
CDC recommends annual chlamydia screening for all sexually active women younger than 25. The U.S. Preventive Services Task Force recommends screening all high risk, sexually active women for gonorrhea. CDC agrees with that recommendation.
Toney is affiliated with a Southeast Regional STD-HIV Prevention Training Center in Tampa that trains health-care providers in diagnosing, treating and managing sexually transmitted diseases, including HIV. Its standard courses are one to five days long, but there are some alternatives.
The center formed in 1988 because of Florida’s high rates of sexually transmitted diseases. It has gotten CDC funding since then. It’s also the only state-supported STD-HIV prevention center of this type.
The Hillsborough County Health Department also is involved

For the complete article, please refer to http://www.theledger.com/article/20090626/NEWS/906265055/1410?Title=Worry-Over-AIDS-Hides-Rising-STD-Infections

When Teens Are Having Sex

How parents respond to the news that their teen is having sex can open communication lines, or sever them, at a key time in the child’s life, according to Maureen Lyon, a clinical psychologist at Children’s National Medical Center in Washington.

Lyon and Christina Breda Antoniades recently wrote a guide that aims to steer parents toward appropriate ways to respond to such a revelation: “My Teen Has Had Sex, Now What Do I Do?” (Fair Winds Press).

“We wanted to provide ways kids and parents could talk,” said Lyon. In her work, she sees the results of poor parent-teen communication on the topic: STDs, unwed pregnancies, and broken relationships.

Though many parents prefer to think that their teen is not sexually active, the book cites statistics that suggest otherwise: 17 percent of seventh- and eighth-graders have had sex at least once, as have 33 percent of ninth-graders, 44 percent of 10th-graders, 56 percent of 11th-graders, and 65 percent of 12th-graders.

Lyon said parents should try to adopt as neutral and non-judgmental a tone as possible. Arguing and screaming often serve only to inflame an already difficult situation, she cautioned. “This can be a teachable moment about the value of sex in the context of a relationship,” said Lyon. “It doesn’t have to end up being a power struggle.”

“First, find the right time, a time when you’ll be uninterrupted and calm, and a private place to speak truthfully from your heart,” Lyon suggests. “Second, share with your teen what your values are and what your concerns are. Third, now that he or she has engaged in adult sexual behavior, let them know you have scheduled an appointment to meet with their pediatrician or adolescent medicine or family doctor for a checkup.”

For the complete article, and for more information from the Centers for Disease Control and Prevention, please refer to http://www.cdcnpin.org/

HPV: Is your daughter at risk?

What do you call a condition that’s widespread in humans and often symptom-free, yet can lead to cancer? Dangerous.
According to the Centers for Disease Control and Prevention, as many as one in four women are infected with the human papillomavirus (HPV), and the numbers are rising, especially among young women.

Some HPV types can cause genital warts. Other HPV types can cause cancer in the genital area. But most people who have HPV don’t know it, because the virus often has no signs or symptoms. Because of this, the virus can spread without any parties involved becoming aware of its transmission.

According to the CDC, about 20 million Americans are infected with HPV. Another 6.2 million Americans become infected each year. About 74 percent of new infections occur in 15- to 24-year-old men and women.
“It is very prevalent,” said Diana Gaviria, Health Officer for the Berkeley County (W.Va.) Health Department. “We see women from their mid-teens up through their 30s being diagnosed, and I’d say that most of them are women in their teens and 20s.”

The CDC predicts more than half of all sexually active men and women will become infected at some time in their lives. “HPV is such a common virus that anyone who is sexually active can come in contact with it and become infected,” Gaviria said.
According to CDC, HPV is only transmitted through sexual contact. However, intercourse is not necessary because it can be transmitted with any kind of genital contact with someone who has HPV. The virus is not found in bodily fluids.

For the complete article, please refer to http://www.herald-mail.com/?cmd=displaystory&story_id=226664&format=html

WHO Approves Cervical Cancer Vaccine Cervarix

The World Health Organization has approved GlaxoSmithKline’s (GSK) Cervarix, paving the way for UN agencies and partners to buy the human papillomavirus (HPV) vaccine for poor countries worldwide.

Certain HPV strains are responsible for most cases of cervical cancer. Of the 280,000 cervical cancer deaths globally, more than 80 percent occur in developing countries. Screening and treatment programs have dramatically reduced the disease’s incidence in developed countries.

Last year, GAVI, formerly known as the Global Alliance for Vaccines and Immunization, made purchasing cervical cancer vaccines for the world’s 73 poorest countries a priority. GAVI, comprising the Bill & Melinda Gates Foundation, UN agencies, and the World Bank among others, is a major buyer of vaccines for the developing world.

Though it has not been approved for use in the United States or Japan, Cervarix is available in 97 other countries. The US Food and Drug Administration is expected to decide whether to approve Cervarix in the coming months. Currently, the only HPV vaccine available for the US market is Merck & Co.’s Gardasil. Cervarix has won more contracts from government health programs beyond the United States.

Both vaccines typically cost around $360 for a three-shot dose. It is not clear whether GSK will discount Cervarix for distribution in poor countries.

For the complete article, and more information from the Centers for Disease Control and Prevention, please refer to http://www.cdcnpin.org/

GlaxoSmithKline Says HPV Vaccine Worked in Study

Reporting the results of a study published in the Lancet, GlaxoSmithKline PLC (GSK) said Tuesday that its human papillomavirus vaccine Cervarix was effective not only against HPV strains most likely to cause cervical cancer but also other strains of the STD.

The subjects of the late-stage trial were 18,644 females ages 15 to 25. They included females with evidence of past or current HPV infection or high-grade Pap smear results, plus others with no evidence of current or previous HPV infection. Case subjects received Cervarix; control subjects received hepatitis A vaccine. The shots were administered at baseline, one month and six months.

The trial sought to test the efficacy of Cervarix against HPV types 16 and 18, the strains most likely to result in cervical cancer. Women who received all three doses of the HPV vaccine achieved 92.9 percent protection. Excluding some lesions not likely caused by HPV types 16 or 18, GSK said the vaccine provided 98.1 percent protection against those strains. In addition, the researchers noted evidence that Cervarix was protective against HPV types 31, 33, and 45. GSK said this was the first time any HPV vaccine evidenced significant protection against precancerous lesions caused by other HPV strains.

Cervarix is already in use in the European Union and many other nations. A decision by the Food and Drug Administration on whether to approve the vaccine for use in the United States could come by autumn.

The report, “Efficacy of Human Papillomavirus (HPV)-16/18 AS04-Adjuvanted Vaccine Against Cervical Infection and Precancer Caused by Oncogenic HPV Types (PATRICIA): Final Analysis of a Double-Blind, Randomized Study in Young Women,” was published in the Lancet (07.07.09; doi:10.1016/S0140-6736(09)61248-4).

For the complete article, and more information from the Centers for Disease Control and Prevention, please refer to http://www.cdcnpin.org/.

Health District Cuts $400,000 Grant that Helped HIV Sufferers Stay on Medications, Navigate Insurance System

On Wednesday, the Palm Beach County Health Care District board unanimously approved a planned $400,000 cut to the Comprehensive AIDS Program’s case management services despite testimony from 10 patients and providers that the services are vital.

Case management helps patients to stay on complex drug regimens, navigate insurance plans, and keep important appointments, advocates told the board. “If a person stops taking their medication, not only does their own health suffer, they become more infectious to other people,” said Yolette Bonnet, CEO of the AIDS program.

Anita Byrd of West Palm Beach said: “I was addicted to street drugs, and I have been clean now for 11 years because of case management. They found me in places where people never want to come.”

The HIV/AIDS grant was among a raft of cuts the board made in its tentative 2010 spending plan. Out of a $250 million budget, the special taxing district must slash $31 million due to increased demands on its insurance programs, which will serve nearly 40,000 people this year. School nurses’ hours were cut from 40 hours a week to 33 to save $3 million.

Jonathan Satter, the board’s chair, said he felt “darned if he did, darned if he didn’t” cut services or raise taxes to preserve them. “We cannot be the sole source for every program,” he said, noting he hoped the AIDS program was seeking foundation money.

For the complete article, and for more information from the Centers for Disease Control and Prevention, please refer to http://www.cdcnpin.org/

FDA Approves Expanded Use Of HIV Drug

Merck announced on Thursday that the FDA has approved expanded use of its HIV drug, Isentress, Reuters. Isentress has been FDA-approved since 2007, but was limited “to use in patients who had drug-resistant strains or were failing on other therapies, also in combination with other HIV drugs. Now it can be used in all adult patients,” the AP/CNBC.com reports. According to AP/CNBC.com, “Isentress is an integrase inhibitor, meaning it works by blocking the enzyme integrase, one of three types of enzymes the AIDS virus uses to reproduce and infect cells”

For the full article, please refer to http://www.medicalnewstoday.com/articles/157219.php

CDC Releases Latest STD Statistics

Yikes—19 million STD infections occur each year according to the Center for Disease Control’s NEW report this week. The numbers from 2007 are in and the stats are a total bummer. Gonorrhea and chlamydia, the most common STDs, recorded the largest number of known cases to date in 2009, 1.5 million according to the most recent assessment.

However, the government agency thinks that’s a low estimate, and suspect that there are actually twice as many people who are carrying the infections. Unfortunately, the infections often go undiagnosed because they can be asymptomatic.

While gonorrhea and chlamydia frequently come together in one big STD package, they are both cured with antibiotics. However, if someone isn’t a responsible sexy time partner and doesn’t get tested regularly, the diseases can wreak havoc and even do things jeopardize your ability to get pregnant.

Since young women, age 15-34, are in the highest risk categories, it’s essential that we take care of our business!

For the full article http://www.thefrisky.com/post/246-cdc-releases-latest-std-statistics/

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